Statistical Analysis of Next Generation Sequencing Data
Somnath Datta • Dan Nettleton
In the last five or so years, next generation sequencing (NGS) technology has been changing the face of biomedical research, replacing the old (micro)- array technology in many ways. Overall, NGS offers a more accurate and cost effective means of studying a variety of genomic signals with a wide range of applications. With any new high-throughput technology come new data analytic challenges. Statisticians are in a unique position to make a difference in this exciting new interdisciplinary area by offering valid methods for studying signals in noisy data and the means to compare signals across multiple experimental conditions. Statistical methods for this relatively new data type have been sufficiently developed to warrant compilation of this book, which in turn may generate further interest in NGS technology amongst statisticians and lead to additional advances in the field.